Alzheimer's disease : methods and protocols by N M Hooper; Humana Press PDF

By N M Hooper; Humana Press

ISBN-10: 0585395071

ISBN-13: 9780585395074

ISBN-10: 0896037371

ISBN-13: 9780896037373

ISBN-10: 1592591957

ISBN-13: 9781592591954

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1. General Comments All of these agents have a narrow therapeutic window. Efficacy is strongly dose dependent, however. Peripheral tolerance to the gastrointestinal side effects develops slowly; hence, all of the agents must be titrated slowly. 2. Pharmacology There are many differences between the four drugs. TAC has a short plasma half-life and is a reversible inhibitor of cholinesterase (28). DON has a long plasma half-life and is also a reversible CEI (29). MET is a prodrug that is nonenzymatically converted to dichlorvos, an irreversible CEI (23).

104. Murphy G. , Sullivan, E. , Thompson, L. , van Duijn, C. , Forno, L. , et al. (1997) No association between the alpha-1-antichymotrypsin A allele and Alzheimer’s disease. Neurology 48, 1313–1316. 105. , Schinka, et al. (1997) No interaction between the ApoE and the alpha-1-antichymotrysin genes on risk for Alzheimer’s disease. Am. J. Med. Genet. 74, 192–194. 106. Lehmann, D. , and Smith, A. D. (1997) Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late onset confirmed Alzheimer’s Disease.

Mol. Genet. 6, 1933–1936. 107. , Masters, C. , and Heuser, I. (1998) Butyrylcholinesterase K variant (BCHE-K): association with late-onset Alzheimer’s disease. Neurobiol. Aging 19, S69. 108. , et al. (1998) Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer’s disease and aging. Hum. Mol. Genet. 7, 933–935. 109. Singleton, A. , Gibson, A. , et al. (1998) No association between the K variant of the butyrylcholinesterase gene and pathologically confirmed Alzheimer’s disease.

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Alzheimer's disease : methods and protocols by N M Hooper; Humana Press


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